Loading ...THE MULTITARGETED APPROACH TO SCREENING
Fast-forwarding to the present technology, the Cologuard is a new and revised stool DNA test. It detects aberrant methylation markers on 2 promoter genes (BPM3 and NDRG4) as well as KRAS mutations, and beta-actin, which is a reference gene for human DNA quantity. In addition to those 4 biomarkers, Cologuard includes a fecal immunohistochemical test (FIT). This is the Polymedco test, and it is set at 100 ng of hemoglobin per mL of buffer. This is the standard threshold used in screening trials for FIT, and it was added to increase the sensitivity of detection of colon cancer.
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